Instrumentation

Equipment Manufacturer Description
Isolera One Purification System Biotage Medium throughput compound purification system
Combiflash RF Flash Chromatography System Teledyne-ISCO Medium throughput compound purification system
Initiator 8-EXP Microwave Biotage Microwave reactor
Capillary Melting Point Apparatus MEL-TEMP Melting point apparatus
Laborota w/ pump and rotacool Heidolph Organic solvent removal
Solvent Purification System PURESOLV Solvent purification/drying
3200 Lauda Low Temperature Chiller WKL Reaction temperature controller
DP63 Vacuum Drying Oven Yamada Drying oven
Lyophilizer System Labconco High-boiling solvent removal
Spectrum One FT-IR Spectrometer Perkin Elmer Spectrometer
AUTOPOL® Automatic Polarimeter Rudolph Research Optical Rotation Measurements
1100 Series LC/MS Agilent Walk-up liquid chromatography/mass spectrometery system
Karl Fischer Titration Apparatus Brinkmann Residual water determination
H-Cube Continuous-flow Hydrogenation Reactor Thales Nanotechnology Flow-through hydrogenation apparatus
Ozonolysis Apparatus Ozotech Ozonolysis apparatus

In addition, a great deal of additional specialized synthesis equipment is available to COBRE researchers on a shared basis with other SBC occupants.

Equipment Manufacturer Description
400 MHz NMR spectrometer (2) Bruker Nuclear magnetic resonance spectrometer
Acquity walk-up LCT Premier LC/MS/UPLC Waters High performance liquid chromatography purification
FTIR w/ Universal Attenuated Total Reflection Perkin Elmer Infrared spectrometry
Combiflash RF Flash Chromatography system (2) Teledyne-ISCO Medium throughput compound purification system
Combiflash Companion Flash Chromatography system Teledyne-ISCO Medium throughput compound purification system
GC/MS 5975C VL MSD/6850 Diff Pump El System w/ autosampler Agilent Gas chromatography system
Initiator 8-EXP Microwave Biotage Microwave
EZ2 Plus HCl Parallel Evaporation System Genevac Solvent removal in parallel
DD4 Parallel Evaporation System Genevac Solvent removal in parallel
High Pressure Hydrogenation Reactor Parr Hydrogenation (classical)
Parallel Synthesis MiniBlock and MiniBlock XT Mettler Toledo Suite of equipment for library preparation and compound handling